<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019eee48-34aa-7d7a-b95c-603bb3d15a4c,g:b04d0faf-b914-44ce-8062-cab62d70df35-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDFINANCIALPOSITION" xlink:type="simple" xlink:href="nbx-20260630.xsd#INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDFINANCIALPOSITION"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDFINANCIALPOSITION" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_019eee48-39ef-7ded-88af-33297bb2fcc9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTradeReceivables_019eee48-39ef-736f-9ba8-bc8e62fc1697" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentTradeReceivables"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019eee48-39ef-7ded-88af-33297bb2fcc9" xlink:to="loc_ifrs-full_CurrentTradeReceivables_019eee48-39ef-736f-9ba8-bc8e62fc1697" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentAssets_019eee48-39ef-79de-9e17-845f89a5d299" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019eee48-39ef-7ded-88af-33297bb2fcc9" xlink:to="loc_ifrs-full_OtherCurrentAssets_019eee48-39ef-79de-9e17-845f89a5d299" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_019eee48-39ef-7cd2-8a22-a7d94f47561d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_019eee48-39ef-7ded-88af-33297bb2fcc9" xlink:to="loc_ifrs-full_CashAndCashEquivalents_019eee48-39ef-7cd2-8a22-a7d94f47561d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_019eee48-39ef-71c3-b6ca-e3d649d3d9c1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_019eee48-39ef-7dc3-b91c-9bf3e0998717" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_019eee48-39ef-71c3-b6ca-e3d649d3d9c1" xlink:to="loc_ifrs-full_NoncurrentAssets_019eee48-39ef-7dc3-b91c-9bf3e0998717" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_019eee48-39ef-7f19-9831-9e8c8faf989e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_019eee48-39ef-71c3-b6ca-e3d649d3d9c1" xlink:to="loc_ifrs-full_CurrentAssets_019eee48-39ef-7f19-9831-9e8c8faf989e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_019eee48-39ef-7e2e-9848-eae3ecf850bd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_019eee48-39ef-7b23-8875-c756678b4fd7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_019eee48-39ef-7e2e-9848-eae3ecf850bd" xlink:to="loc_ifrs-full_NoncurrentLiabilities_019eee48-39ef-7b23-8875-c756678b4fd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-74ae-9bbd-099b6fdf811a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_019eee48-39ef-7e2e-9848-eae3ecf850bd" xlink:to="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-74ae-9bbd-099b6fdf811a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_019eee48-39ef-7beb-9674-db1eb8a896a6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_019eee48-39ef-70fa-9783-73a0aa0847b1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_019eee48-39ef-7beb-9674-db1eb8a896a6" xlink:to="loc_ifrs-full_Equity_019eee48-39ef-70fa-9783-73a0aa0847b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_019eee48-39ef-7a3b-8c78-93e8494de984" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_019eee48-39ef-7beb-9674-db1eb8a896a6" xlink:to="loc_ifrs-full_Liabilities_019eee48-39ef-7a3b-8c78-93e8494de984" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_019eee48-39ef-7b18-9e92-bdc4d200ca7b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_019eee48-39ef-7725-914a-7f683df22fc3" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019eee48-39ef-7b18-9e92-bdc4d200ca7b" xlink:to="loc_ifrs-full_IssuedCapital_019eee48-39ef-7725-914a-7f683df22fc3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_019eee48-39ef-75aa-b9a3-8d8a43c89116" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SharePremium"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019eee48-39ef-7b18-9e92-bdc4d200ca7b" xlink:to="loc_ifrs-full_SharePremium_019eee48-39ef-75aa-b9a3-8d8a43c89116" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AccumulatedOtherComprehensiveIncome_019eee48-39ef-7c24-a31c-ba22ec2fd049" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AccumulatedOtherComprehensiveIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019eee48-39ef-7b18-9e92-bdc4d200ca7b" xlink:to="loc_ifrs-full_AccumulatedOtherComprehensiveIncome_019eee48-39ef-7c24-a31c-ba22ec2fd049" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasuryShares_019eee48-39ef-7365-a465-5a4bcb540f92" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TreasuryShares"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019eee48-39ef-7b18-9e92-bdc4d200ca7b" xlink:to="loc_ifrs-full_TreasuryShares_019eee48-39ef-7365-a465-5a4bcb540f92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_019eee48-39ef-7106-a5be-3e9813d76b3d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019eee48-39ef-7b18-9e92-bdc4d200ca7b" xlink:to="loc_ifrs-full_OtherReserves_019eee48-39ef-7106-a5be-3e9813d76b3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarningsProfitLossForReportingPeriod_019eee48-39ef-7d86-8daf-c602231c3931" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RetainedEarningsProfitLossForReportingPeriod"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_019eee48-39ef-7b18-9e92-bdc4d200ca7b" xlink:to="loc_ifrs-full_RetainedEarningsProfitLossForReportingPeriod_019eee48-39ef-7d86-8daf-c602231c3931" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_019eee48-39ef-78e4-8e17-9acf24313af1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilities_019eee48-39ef-7e7b-ae64-1de7eea23e3a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentFinancialLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019eee48-39ef-78e4-8e17-9acf24313af1" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilities_019eee48-39ef-7e7b-ae64-1de7eea23e3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions_019eee48-39ef-7aa1-aefd-2b48f2a675fa" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019eee48-39ef-78e4-8e17-9acf24313af1" xlink:to="loc_ifrs-full_NoncurrentProvisions_019eee48-39ef-7aa1-aefd-2b48f2a675fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractLiabilities_019eee48-39ef-7a97-982c-329eed934b44" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentContractLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_019eee48-39ef-78e4-8e17-9acf24313af1" xlink:to="loc_ifrs-full_NoncurrentContractLiabilities_019eee48-39ef-7a97-982c-329eed934b44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_019eee48-39ef-75f6-85ad-3f576bbe2a27" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_019eee48-39ef-729e-9f25-ce3c0a22b752" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019eee48-39ef-75f6-85ad-3f576bbe2a27" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_019eee48-39ef-729e-9f25-ce3c0a22b752" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_019eee48-39ef-7afe-a732-9ef9817d2bff" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019eee48-39ef-75f6-85ad-3f576bbe2a27" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_019eee48-39ef-7afe-a732-9ef9817d2bff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssets_019eee48-39ef-7a1d-a98b-fdc81cb4cccf" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentFinancialAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_019eee48-39ef-75f6-85ad-3f576bbe2a27" xlink:to="loc_ifrs-full_NoncurrentFinancialAssets_019eee48-39ef-7a1d-a98b-fdc81cb4cccf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-7ee7-8ef9-72d3f968f9fd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_019eee48-39ef-7271-9924-63612c3936ed" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentProvisions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-7ee7-8ef9-72d3f968f9fd" xlink:to="loc_ifrs-full_CurrentProvisions_019eee48-39ef-7271-9924-63612c3936ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialLiabilities_019eee48-39ef-7784-a797-c9eca2f917f7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-7ee7-8ef9-72d3f968f9fd" xlink:to="loc_ifrs-full_CurrentFinancialLiabilities_019eee48-39ef-7784-a797-c9eca2f917f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_019eee48-39ef-712b-aa86-131c210f0889" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-7ee7-8ef9-72d3f968f9fd" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_019eee48-39ef-712b-aa86-131c210f0889" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentLiabilities_019eee48-39ef-7448-bf30-f0a5cdb6b31f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-7ee7-8ef9-72d3f968f9fd" xlink:to="loc_ifrs-full_OtherCurrentLiabilities_019eee48-39ef-7448-bf30-f0a5cdb6b31f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDeferredIncomeOtherThanCurrentContractLiabilities_019eee48-39ef-7f43-a19f-8bcb01b4899c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentDeferredIncomeOtherThanCurrentContractLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-7ee7-8ef9-72d3f968f9fd" xlink:to="loc_ifrs-full_CurrentDeferredIncomeOtherThanCurrentContractLiabilities_019eee48-39ef-7f43-a19f-8bcb01b4899c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_019eee48-39ef-7651-a3b8-6037450026d1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-7ee7-8ef9-72d3f968f9fd" xlink:to="loc_ifrs-full_CurrentContractLiabilities_019eee48-39ef-7651-a3b8-6037450026d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentRefundsProvision_019eee48-39ef-718e-a562-bd3c7575b738" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentRefundsProvision"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_019eee48-39ef-7ee7-8ef9-72d3f968f9fd" xlink:to="loc_ifrs-full_CurrentRefundsProvision_019eee48-39ef-718e-a562-bd3c7575b738" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDOPERATIONS" xlink:type="simple" xlink:href="nbx-20260630.xsd#INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDOPERATIONS"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_019eee48-39ef-7670-903c-ec362ec80e9b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_019eee48-39ef-72da-921a-96de3cc33c28" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Revenue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019eee48-39ef-7670-903c-ec362ec80e9b" xlink:to="loc_ifrs-full_Revenue_019eee48-39ef-72da-921a-96de3cc33c28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpense_019eee48-39ef-71f8-a3da-7f5752760101" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OperatingExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_019eee48-39ef-7670-903c-ec362ec80e9b" xlink:to="loc_ifrs-full_OperatingExpense_019eee48-39ef-71f8-a3da-7f5752760101" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_019eee48-39ef-7140-97bd-eb46d51b4846" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_019eee48-39ef-724d-85ac-0eb69d283a6c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_019eee48-39ef-7140-97bd-eb46d51b4846" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_019eee48-39ef-724d-85ac-0eb69d283a6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_019eee48-39ef-74e9-9d1d-fbbb84f319d7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_019eee48-39ef-7140-97bd-eb46d51b4846" xlink:to="loc_ifrs-full_FinanceIncomeCost_019eee48-39ef-74e9-9d1d-fbbb84f319d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019eee48-39ef-75d8-b344-356ea20d7934" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_019eee48-39ef-7140-97bd-eb46d51b4846" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019eee48-39ef-75d8-b344-356ea20d7934" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_019eee48-39ef-7247-bdbb-9392a3c1d265" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_019eee48-39ef-7563-819b-2197aa3b9635" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_019eee48-39ef-7247-bdbb-9392a3c1d265" xlink:to="loc_ifrs-full_FinanceCosts_019eee48-39ef-7563-819b-2197aa3b9635" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_019eee48-39ef-7b9b-95b1-0fec7f5ee0cf" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_019eee48-39ef-7247-bdbb-9392a3c1d265" xlink:to="loc_ifrs-full_FinanceIncome_019eee48-39ef-7b9b-95b1-0fec7f5ee0cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpense_019eee48-39ef-7367-9c2d-5bef77a1ac9c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OperatingExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_019eee48-39ef-7de7-8980-b53b5dbcdc17" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_019eee48-39ef-7367-9c2d-5bef77a1ac9c" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_019eee48-39ef-7de7-8980-b53b5dbcdc17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_019eee48-39ef-70ab-b7a6-9977795af300" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_019eee48-39ef-7367-9c2d-5bef77a1ac9c" xlink:to="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_019eee48-39ef-70ab-b7a6-9977795af300" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_019eee48-39ef-72b6-a746-d9858fa6c5bc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_019eee48-39ef-7367-9c2d-5bef77a1ac9c" xlink:to="loc_ifrs-full_OtherOperatingIncomeExpense_019eee48-39ef-72b6-a746-d9858fa6c5bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_019eee48-39ef-7291-8a6f-f69bb5ff08ef" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Revenue"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_019eee48-39ef-7161-bf8d-3e47f6d66b7c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Revenue_019eee48-39ef-7291-8a6f-f69bb5ff08ef" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_019eee48-39ef-7161-bf8d-3e47f6d66b7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherIncome_019eee48-39ef-7be3-a7ee-1a2e8bf267c7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Revenue_019eee48-39ef-7291-8a6f-f69bb5ff08ef" xlink:to="loc_ifrs-full_OtherIncome_019eee48-39ef-7be3-a7ee-1a2e8bf267c7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="nbx-20260630.xsd#INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-327f-783f-95ca-838490dab85e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_019f3a5f-327f-7811-931f-734a3918616a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-327f-783f-95ca-838490dab85e" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_019f3a5f-327f-7811-931f-734a3918616a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome_019f3a5f-327f-780e-bae2-4b19af0b4941" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-327f-783f-95ca-838490dab85e" xlink:to="loc_ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome_019f3a5f-327f-780e-bae2-4b19af0b4941" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnHedgingInstrumentsThatHedgeInvestmentsInEquityInstruments_01a08c3a-b558-74fd-be0c-5d109e37f3fb" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnHedgingInstrumentsThatHedgeInvestmentsInEquityInstruments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-327f-783f-95ca-838490dab85e" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnHedgingInstrumentsThatHedgeInvestmentsInEquityInstruments_01a08c3a-b558-74fd-be0c-5d109e37f3fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-9d90-7515-970c-c7ab0a7a012f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_019f3a5f-9d90-7da0-8775-beca4d2fc2d4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-9d90-7515-970c-c7ab0a7a012f" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_019f3a5f-9d90-7da0-8775-beca4d2fc2d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToExchangeDifferencesOnTranslationOfOtherComprehensiveIncome_019f3a5f-9d90-7a70-a388-342748c96e37" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxRelatingToExchangeDifferencesOnTranslationOfOtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-9d90-7515-970c-c7ab0a7a012f" xlink:to="loc_ifrs-full_IncomeTaxRelatingToExchangeDifferencesOnTranslationOfOtherComprehensiveIncome_019f3a5f-9d90-7a70-a388-342748c96e37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_019f3a60-355c-7b7a-afd8-9e32e7174ec7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_019f3a60-355c-7dd6-9cd0-3da878773157" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_019f3a60-355c-7b7a-afd8-9e32e7174ec7" xlink:to="loc_ifrs-full_ProfitLoss_019f3a60-355c-7dd6-9cd0-3da878773157" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019f3a60-355c-761e-9963-78a0872de43b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_019f3a60-355c-7b7a-afd8-9e32e7174ec7" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019f3a60-355c-761e-9963-78a0872de43b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_019f3a60-355c-7d3a-bf0d-9070db07aa94" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_019f3a60-355c-7b7a-afd8-9e32e7174ec7" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_019f3a60-355c-7d3a-bf0d-9070db07aa94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_019f3a5f-e7f7-76e8-9dca-d39b891ce2f4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_01a09f9f-cad1-78a3-9fcc-ee6e8a348a23" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_019f3a5f-e7f7-76e8-9dca-d39b891ce2f4" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_01a09f9f-cad1-78a3-9fcc-ee6e8a348a23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-e7f7-76f4-8327-f2eb64e611de" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_019f3a5f-e7f7-76e8-9dca-d39b891ce2f4" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_019f3a5f-e7f7-76f4-8327-f2eb64e611de" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCASHFLOWS" xlink:type="simple" xlink:href="nbx-20260630.xsd#INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCASHFLOWS"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-72de-9c4d-18d0700ae1fc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable_019eee48-39ef-7e69-b040-2a0f42c08588" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-72de-9c4d-18d0700ae1fc" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable_019eee48-39ef-7e69-b040-2a0f42c08588" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_AdjustmentsForDecreaseIncreaseInReceivablesFromTaxesOtherThanIncomeTax_019eee48-39ef-72f5-9dd9-8751865c3c54" xlink:href="nbx-20260630.xsd#nbx_AdjustmentsForDecreaseIncreaseInReceivablesFromTaxesOtherThanIncomeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-72de-9c4d-18d0700ae1fc" xlink:to="loc_nbx_AdjustmentsForDecreaseIncreaseInReceivablesFromTaxesOtherThanIncomeTax_019eee48-39ef-72f5-9dd9-8751865c3c54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_AdjustmentsForDecreaseIncreaseInOtherReceivables_019eee48-39ef-7ca5-a84e-1788655f2a54" xlink:href="nbx-20260630.xsd#nbx_AdjustmentsForDecreaseIncreaseInOtherReceivables"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-72de-9c4d-18d0700ae1fc" xlink:to="loc_nbx_AdjustmentsForDecreaseIncreaseInOtherReceivables_019eee48-39ef-7ca5-a84e-1788655f2a54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables_019eee48-39ef-704c-83e4-d283857e2c28" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-72de-9c4d-18d0700ae1fc" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables_019eee48-39ef-704c-83e4-d283857e2c28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherCurrentLiabilities_019eee48-39ef-7464-94ca-cf74c7f383f2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInOtherCurrentLiabilities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-72de-9c4d-18d0700ae1fc" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherCurrentLiabilities_019eee48-39ef-7464-94ca-cf74c7f383f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDeferredIncomeIncludingContractLiabilities_019eee48-39ef-7343-8456-a326854ce705" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInDeferredIncomeIncludingContractLiabilities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-72de-9c4d-18d0700ae1fc" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDeferredIncomeIncludingContractLiabilities_019eee48-39ef-7343-8456-a326854ce705" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_AdjustmentsForIncreaseDecreaseInRefundLiability_01a08c2c-6d0c-7ab0-9b85-453cedacae66" xlink:href="nbx-20260630.xsd#nbx_AdjustmentsForIncreaseDecreaseInRefundLiability"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-72de-9c4d-18d0700ae1fc" xlink:to="loc_nbx_AdjustmentsForIncreaseDecreaseInRefundLiability_01a08c2c-6d0c-7ab0-9b85-453cedacae66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_019eee48-39ef-77e3-b9be-b4c3239a64f8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019eee48-39ef-7b28-8807-202444b7014c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_019eee48-39ef-77e3-b9be-b4c3239a64f8" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019eee48-39ef-7b28-8807-202444b7014c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019eee48-39ef-7dee-88d6-a661fecb3b29" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_019eee48-39ef-77e3-b9be-b4c3239a64f8" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019eee48-39ef-7dee-88d6-a661fecb3b29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-78d0-80c7-59b6ff77195a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_019eee48-39ef-77e3-b9be-b4c3239a64f8" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-78d0-80c7-59b6ff77195a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_019eee48-39ef-7533-b9e6-8e5ddec18cdd" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_019eee48-39ef-77e3-b9be-b4c3239a64f8" xlink:to="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_019eee48-39ef-7533-b9e6-8e5ddec18cdd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7418-9d2f-59b90100f9f8" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_CashFlowFromOperatingActivitiesAfterTaxAndBeforeChangeInWorkingCapitalRequirement_019eee48-39ef-77ee-965c-30b2123d084e" xlink:href="nbx-20260630.xsd#nbx_CashFlowFromOperatingActivitiesAfterTaxAndBeforeChangeInWorkingCapitalRequirement"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7418-9d2f-59b90100f9f8" xlink:to="loc_nbx_CashFlowFromOperatingActivitiesAfterTaxAndBeforeChangeInWorkingCapitalRequirement_019eee48-39ef-77ee-965c-30b2123d084e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities_019eee48-39ef-7120-afa2-cfc0da4e0783" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7418-9d2f-59b90100f9f8" xlink:to="loc_ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities_019eee48-39ef-7120-afa2-cfc0da4e0783" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesRefundClassifiedAsOperatingActivities_01a08c18-38a0-7aec-963d-fb66e9b41ad4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxesRefundClassifiedAsOperatingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7418-9d2f-59b90100f9f8" xlink:to="loc_ifrs-full_IncomeTaxesRefundClassifiedAsOperatingActivities_01a08c18-38a0-7aec-963d-fb66e9b41ad4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019eee48-39ef-71af-9d44-ceddab142518" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_019eee48-39ef-7e20-bfc7-6f5141d78d6d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019eee48-39ef-71af-9d44-ceddab142518" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_019eee48-39ef-7e20-bfc7-6f5141d78d6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_019eee48-39ef-7337-9358-830521cafda9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019eee48-39ef-71af-9d44-ceddab142518" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_019eee48-39ef-7337-9358-830521cafda9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities_019eee48-39ef-7e6f-a564-8f869d6b364f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019eee48-39ef-71af-9d44-ceddab142518" xlink:to="loc_ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities_019eee48-39ef-7e6f-a564-8f869d6b364f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromOtherLongtermAssetsClassifiedAsInvestingActivities_01a08c1b-c7f5-7ae1-b422-9671c6274d0c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromOtherLongtermAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_019eee48-39ef-71af-9d44-ceddab142518" xlink:to="loc_ifrs-full_ProceedsFromOtherLongtermAssetsClassifiedAsInvestingActivities_01a08c1b-c7f5-7ae1-b422-9671c6274d0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019eee48-39ef-71b8-ac8f-3ccbf25a33bc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-797d-a8e2-689fdc95039f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019eee48-39ef-71b8-ac8f-3ccbf25a33bc" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-797d-a8e2-689fdc95039f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-7148-9fc6-dedb9eff5d0f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019eee48-39ef-71b8-ac8f-3ccbf25a33bc" xlink:to="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_019eee48-39ef-7148-9fc6-dedb9eff5d0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities_019eee48-39ef-7499-abaf-3c9880f3536e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019eee48-39ef-71b8-ac8f-3ccbf25a33bc" xlink:to="loc_ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities_019eee48-39ef-7499-abaf-3c9880f3536e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesRefundClassifiedAsOperatingActivities_01a08c17-f9ab-7f59-968d-86c14e96fdfc" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxesRefundClassifiedAsOperatingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019eee48-39ef-71b8-ac8f-3ccbf25a33bc" xlink:to="loc_ifrs-full_IncomeTaxesRefundClassifiedAsOperatingActivities_01a08c17-f9ab-7f59-968d-86c14e96fdfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-75f4-a424-e56c2322e11d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfOrdinaryShares_019eee48-39ef-7cb3-8036-deb67d0800ec" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromIssueOfOrdinaryShares"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-75f4-a424-e56c2322e11d" xlink:to="loc_ifrs-full_ProceedsFromIssueOfOrdinaryShares_019eee48-39ef-7cb3-8036-deb67d0800ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromExerciseOfWarrants_01a08c30-6d53-727d-9b78-196c60aafb59" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromExerciseOfWarrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-75f4-a424-e56c2322e11d" xlink:to="loc_ifrs-full_ProceedsFromExerciseOfWarrants_01a08c30-6d53-727d-9b78-196c60aafb59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_PaymentOfTransactionCosts_019eee48-39ef-7c12-b08c-470c1069a91d" xlink:href="nbx-20260630.xsd#nbx_PaymentOfTransactionCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-75f4-a424-e56c2322e11d" xlink:to="loc_nbx_PaymentOfTransactionCosts_019eee48-39ef-7c12-b08c-470c1069a91d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_019eee48-39ef-763e-9dfe-d3071ac699ab" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-75f4-a424-e56c2322e11d" xlink:to="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_019eee48-39ef-763e-9dfe-d3071ac699ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_019eee48-39ef-729c-8ee3-a605f3e42638" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-75f4-a424-e56c2322e11d" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_019eee48-39ef-729c-8ee3-a605f3e42638" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_01a09f99-1c67-73d2-8505-db41959c277b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestPaidClassifiedAsFinancingActivities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_019eee48-39ef-75f4-a424-e56c2322e11d" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_01a09f99-1c67-73d2-8505-db41959c277b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCASHFLOWS_1" xlink:type="simple" xlink:href="nbx-20260630.xsd#INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCASHFLOWS_1"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/INTERIMCONDENSEDSTATEMENTSOFCONSOLIDATEDCASHFLOWS_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_019eee48-39ef-70d4-8f98-70420b9bc16f" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_ifrs-full_ProfitLoss_019eee48-39ef-70d4-8f98-70420b9bc16f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_019eee48-39ef-7b56-8c0c-dc8b485291ef" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_019eee48-39ef-7b56-8c0c-dc8b485291ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForProvisions_019eee48-39ef-7a8f-b82a-5833fdcb0e70" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForProvisions"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_ifrs-full_AdjustmentsForProvisions_019eee48-39ef-7a8f-b82a-5833fdcb0e70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_019eee48-39ef-754d-9f22-9eb7237f344e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_019eee48-39ef-754d-9f22-9eb7237f344e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceCosts_019eee48-39ef-75de-880f-a7744d1642e4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForFinanceCosts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_ifrs-full_AdjustmentsForFinanceCosts_019eee48-39ef-75de-880f-a7744d1642e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities_019eee48-39ef-725c-afc1-f2097ea2e085" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities_019eee48-39ef-725c-afc1-f2097ea2e085" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019eee48-39ef-7ecc-9b7a-023b7d629e4b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_019eee48-39ef-7ecc-9b7a-023b7d629e4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_ImpactOfAmendmentOnProfitOrLoss_019eee48-39ef-7c1d-92bb-f1e366b8624c" xlink:href="nbx-20260630.xsd#nbx_ImpactOfAmendmentOnProfitOrLoss"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_nbx_ImpactOfAmendmentOnProfitOrLoss_019eee48-39ef-7c1d-92bb-f1e366b8624c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsForNoncashItems_019eee48-39ef-7962-b144-d7d3ec0b3035" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherAdjustmentsForNoncashItems"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_019eee48-39ef-7999-b206-af3be45a8d32" xlink:to="loc_ifrs-full_OtherAdjustmentsForNoncashItems_019eee48-39ef-7962-b144-d7d3ec0b3035" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/TradereceivablesandothercurrentassetsScheduleofOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#TradereceivablesandothercurrentassetsScheduleofOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/TradereceivablesandothercurrentassetsScheduleofOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentAssets_019eee48-39ef-7632-b0ac-841237f47bc2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentReceivablesFromTaxesOtherThanIncomeTax_019eee48-39ef-7443-a76f-a25413424104" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentReceivablesFromTaxesOtherThanIncomeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentAssets_019eee48-39ef-7632-b0ac-841237f47bc2" xlink:to="loc_ifrs-full_CurrentReceivablesFromTaxesOtherThanIncomeTax_019eee48-39ef-7443-a76f-a25413424104" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentValueAddedTaxReceivables_019eee48-39ef-7616-9b86-bf4b940fad69" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentValueAddedTaxReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentAssets_019eee48-39ef-7632-b0ac-841237f47bc2" xlink:to="loc_ifrs-full_CurrentValueAddedTaxReceivables_019eee48-39ef-7616-9b86-bf4b940fad69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPrepaidExpenses_019eee48-39ef-7d5d-bff1-2479d0c3c8a2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentPrepaidExpenses"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentAssets_019eee48-39ef-7632-b0ac-841237f47bc2" xlink:to="loc_ifrs-full_CurrentPrepaidExpenses_019eee48-39ef-7d5d-bff1-2479d0c3c8a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentReceivables_019eee48-39ef-7e1a-9c5a-a5d84e6367b5" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentReceivables"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentAssets_019eee48-39ef-7632-b0ac-841237f47bc2" xlink:to="loc_ifrs-full_OtherCurrentReceivables_019eee48-39ef-7e1a-9c5a-a5d84e6367b5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/CashandcashequivalentsScheduleofCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#CashandcashequivalentsScheduleofCashandCashEquivalentsDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/CashandcashequivalentsScheduleofCashandCashEquivalentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_019eee48-39ef-766f-a0f8-7644fbcbbea1" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Cash_019eee48-39ef-7cbc-a76e-619cf332ee95" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Cash"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_019eee48-39ef-766f-a0f8-7644fbcbbea1" xlink:to="loc_ifrs-full_Cash_019eee48-39ef-7cbc-a76e-619cf332ee95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShorttermDepositsClassifiedAsCashEquivalents_019eee48-39ef-70a3-9fc3-05909a94b4c2" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ShorttermDepositsClassifiedAsCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_019eee48-39ef-766f-a0f8-7644fbcbbea1" xlink:to="loc_ifrs-full_ShorttermDepositsClassifiedAsCashEquivalents_019eee48-39ef-70a3-9fc3-05909a94b4c2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/FinancialliabilitiesScheduleofChangesinFinancialLiabilitiesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#FinancialliabilitiesScheduleofChangesinFinancialLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/FinancialliabilitiesScheduleofChangesinFinancialLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialLiabilities_019eee48-3a89-706d-8bb9-6d7ca26dd2a7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinancialLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialLiabilities_019eee48-3a89-7430-b85b-f6ef6657c24a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentFinancialLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019eee48-3a89-706d-8bb9-6d7ca26dd2a7" xlink:to="loc_ifrs-full_CurrentFinancialLiabilities_019eee48-3a89-7430-b85b-f6ef6657c24a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilities_019eee48-3a89-73ae-9438-55bcb2bcb508" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinancialLiabilities_019eee48-3a89-706d-8bb9-6d7ca26dd2a7" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilities_019eee48-3a89-73ae-9438-55bcb2bcb508" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/FinancialliabilitiesScheduleofChangesinLiabilitiesArisingfromFinancingActivitiesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#FinancialliabilitiesScheduleofChangesinLiabilitiesArisingfromFinancingActivitiesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/FinancialliabilitiesScheduleofChangesinLiabilitiesArisingfromFinancingActivitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LiabilitiesArisingFromFinancingActivities_019eee48-3a89-784c-8482-eee09a949b30" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LiabilitiesArisingFromFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_LiabilitiesArisingFromFinancingActivitiesCurrent_019eee48-3a89-7eb7-ab0a-8741721918ba" xlink:href="nbx-20260630.xsd#nbx_LiabilitiesArisingFromFinancingActivitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_LiabilitiesArisingFromFinancingActivities_019eee48-3a89-784c-8482-eee09a949b30" xlink:to="loc_nbx_LiabilitiesArisingFromFinancingActivitiesCurrent_019eee48-3a89-7eb7-ab0a-8741721918ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_LiabilitiesArisingFromFinancingActivitiesNonCurrent_019eee48-3a89-7ac5-94cd-0ff1880422d1" xlink:href="nbx-20260630.xsd#nbx_LiabilitiesArisingFromFinancingActivitiesNonCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_LiabilitiesArisingFromFinancingActivities_019eee48-3a89-784c-8482-eee09a949b30" xlink:to="loc_nbx_LiabilitiesArisingFromFinancingActivitiesNonCurrent_019eee48-3a89-7ac5-94cd-0ff1880422d1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/TradepayablesandothercurrentliabilitiesScheduleofTradeandOtherPayablesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#TradepayablesandothercurrentliabilitiesScheduleofTradeandOtherPayablesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/TradepayablesandothercurrentliabilitiesScheduleofTradeandOtherPayablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_019eee48-3a89-794e-a94a-858cf208ae0b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAccruedExpensesAndOtherCurrentLiabilities_019eee48-3a89-7711-8baf-490c8f95145c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAccruedExpensesAndOtherCurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_TradeAndOtherCurrentPayables_019eee48-3a89-794e-a94a-858cf208ae0b" xlink:to="loc_ifrs-full_CurrentAccruedExpensesAndOtherCurrentLiabilities_019eee48-3a89-7711-8baf-490c8f95145c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_019eee48-3a89-72b6-870e-fca6eb72f927" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_TradeAndOtherCurrentPayables_019eee48-3a89-794e-a94a-858cf208ae0b" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_019eee48-3a89-72b6-870e-fca6eb72f927" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/TradepayablesandothercurrentliabilitiesScheduleofOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#TradepayablesandothercurrentliabilitiesScheduleofOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/TradepayablesandothercurrentliabilitiesScheduleofOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentLiabilities_019eee48-3a89-7e65-8e02-88689dd13b65" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_019eee48-3a89-7ad9-9848-34806103cf57" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentLiabilities_019eee48-3a89-7e65-8e02-88689dd13b65" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_019eee48-3a89-7ad9-9848-34806103cf57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPayablesOnSocialSecurityAndTaxesOtherThanIncomeTax_019eee48-3a89-7c20-857c-57d003b69ca9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentPayablesOnSocialSecurityAndTaxesOtherThanIncomeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentLiabilities_019eee48-3a89-7e65-8e02-88689dd13b65" xlink:to="loc_ifrs-full_CurrentPayablesOnSocialSecurityAndTaxesOtherThanIncomeTax_019eee48-3a89-7c20-857c-57d003b69ca9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_OtherMiscellaneousCurrentLiabilities_019eee48-3a89-71f2-be6a-d205e3784c86" xlink:href="nbx-20260630.xsd#nbx_OtherMiscellaneousCurrentLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherCurrentLiabilities_019eee48-3a89-7e65-8e02-88689dd13b65" xlink:to="loc_nbx_OtherMiscellaneousCurrentLiabilities_019eee48-3a89-71f2-be6a-d205e3784c86" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/TradepayablesandothercurrentliabilitiesScheduleofDeferredIncomeandContractLiabilitiesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#TradepayablesandothercurrentliabilitiesScheduleofDeferredIncomeandContractLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/TradepayablesandothercurrentliabilitiesScheduleofDeferredIncomeandContractLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDeferredIncomeIncludingCurrentContractLiabilities_019eee48-3a89-7653-8281-4f07650759a9" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentDeferredIncomeIncludingCurrentContractLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDeferredIncomeOtherThanCurrentContractLiabilities_019eee48-3a89-7ade-99c0-170a28878ea5" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentDeferredIncomeOtherThanCurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentDeferredIncomeIncludingCurrentContractLiabilities_019eee48-3a89-7653-8281-4f07650759a9" xlink:to="loc_ifrs-full_CurrentDeferredIncomeOtherThanCurrentContractLiabilities_019eee48-3a89-7ade-99c0-170a28878ea5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_019eee48-3a89-722f-95b9-8ea3cb48ef76" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentDeferredIncomeIncludingCurrentContractLiabilities_019eee48-3a89-7653-8281-4f07650759a9" xlink:to="loc_ifrs-full_CurrentContractLiabilities_019eee48-3a89-722f-95b9-8ea3cb48ef76" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/TradepayablesandothercurrentliabilitiesScheduleofDeferredIncomeandContractLiabilitiesDetails_1" xlink:type="simple" xlink:href="nbx-20260630.xsd#TradepayablesandothercurrentliabilitiesScheduleofDeferredIncomeandContractLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/TradepayablesandothercurrentliabilitiesScheduleofDeferredIncomeandContractLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RefundsProvision_019eee48-3a89-7d60-9415-3a6d8a34cd95" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RefundsProvision"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentContractLiabilities_019eee48-3a89-7a71-9131-eec1320d4452" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_RefundsProvision_019eee48-3a89-7d60-9415-3a6d8a34cd95" xlink:to="loc_ifrs-full_NoncurrentContractLiabilities_019eee48-3a89-7a71-9131-eec1320d4452" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentRefundsProvision_019eee48-3a89-77b5-8ab1-ad9a4c9d5260" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentRefundsProvision"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_RefundsProvision_019eee48-3a89-7d60-9415-3a6d8a34cd95" xlink:to="loc_ifrs-full_CurrentRefundsProvision_019eee48-3a89-77b5-8ab1-ad9a4c9d5260" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/RevenueandotherincomeScheduleofRevenuesandOtherIncomeDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#RevenueandotherincomeScheduleofRevenuesandOtherIncomeDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/RevenueandotherincomeScheduleofRevenuesandOtherIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherIncome_019eee48-3a89-7d2f-ac97-f551095a8155" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromGovernmentGrants_019eee48-3a89-7b56-8118-6f1d8a020ce4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RevenueFromGovernmentGrants"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_019eee48-3a89-7d2f-ac97-f551095a8155" xlink:to="loc_ifrs-full_RevenueFromGovernmentGrants_019eee48-3a89-7b56-8118-6f1d8a020ce4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingIncome_019eee48-3a89-7fa4-a08f-0ad77c1af11c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_019eee48-3a89-7d2f-ac97-f551095a8155" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingIncome_019eee48-3a89-7fa4-a08f-0ad77c1af11c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_ResearchAndDevelopmentTaxCredit_019eee48-3a89-7e3a-ba7a-d2c33b411f8d" xlink:href="nbx-20260630.xsd#nbx_ResearchAndDevelopmentTaxCredit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_019eee48-3a89-7d2f-ac97-f551095a8155" xlink:to="loc_nbx_ResearchAndDevelopmentTaxCredit_019eee48-3a89-7e3a-ba7a-d2c33b411f8d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/OperatingexpensesScheduleofResearchandDevelopmentExpensesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#OperatingexpensesScheduleofResearchandDevelopmentExpensesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/OperatingexpensesScheduleofResearchandDevelopmentExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_019eee48-3a89-77b4-bc55-5699c6af9b56" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_ResearchAndDevelopmentExpenseSubContractingAndOtherExpenses_019eee48-3a89-7fd2-9527-230d8d8dc19a" xlink:href="nbx-20260630.xsd#nbx_ResearchAndDevelopmentExpenseSubContractingAndOtherExpenses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ResearchAndDevelopmentExpense_019eee48-3a89-77b4-bc55-5699c6af9b56" xlink:to="loc_nbx_ResearchAndDevelopmentExpenseSubContractingAndOtherExpenses_019eee48-3a89-7fd2-9527-230d8d8dc19a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_ResearchAndDevelopmentExpensePayrollCosts_019eee48-3a89-7cf2-a136-455ce9ee4183" xlink:href="nbx-20260630.xsd#nbx_ResearchAndDevelopmentExpensePayrollCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ResearchAndDevelopmentExpense_019eee48-3a89-77b4-bc55-5699c6af9b56" xlink:to="loc_nbx_ResearchAndDevelopmentExpensePayrollCosts_019eee48-3a89-7cf2-a136-455ce9ee4183" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_ResearchAndDevelopmentExpenseDepreciationAmortizationAndProvisionExpense_019eee48-3a89-7bef-a6bf-90cb08a0e598" xlink:href="nbx-20260630.xsd#nbx_ResearchAndDevelopmentExpenseDepreciationAmortizationAndProvisionExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ResearchAndDevelopmentExpense_019eee48-3a89-77b4-bc55-5699c6af9b56" xlink:to="loc_nbx_ResearchAndDevelopmentExpenseDepreciationAmortizationAndProvisionExpense_019eee48-3a89-7bef-a6bf-90cb08a0e598" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/OperatingexpensesScheduleofSellingGeneralandAdministrativeExpensesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#OperatingexpensesScheduleofSellingGeneralandAdministrativeExpensesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/OperatingexpensesScheduleofSellingGeneralandAdministrativeExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_019eee48-3a89-751c-8c1c-ebb962fb8d5c" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SellingGeneralAndAdministrativeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_SellingGeneralAndAdministrativeExpensePurchasesFeesAndOtherExpense_019eee48-3a89-700e-904c-1fd571325d12" xlink:href="nbx-20260630.xsd#nbx_SellingGeneralAndAdministrativeExpensePurchasesFeesAndOtherExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_019eee48-3a89-751c-8c1c-ebb962fb8d5c" xlink:to="loc_nbx_SellingGeneralAndAdministrativeExpensePurchasesFeesAndOtherExpense_019eee48-3a89-700e-904c-1fd571325d12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_SellingGeneralAndAdministrativeExpensePayrollCosts_019eee48-3a89-796a-b153-9dfb4f0f2ff3" xlink:href="nbx-20260630.xsd#nbx_SellingGeneralAndAdministrativeExpensePayrollCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_019eee48-3a89-751c-8c1c-ebb962fb8d5c" xlink:to="loc_nbx_SellingGeneralAndAdministrativeExpensePayrollCosts_019eee48-3a89-796a-b153-9dfb4f0f2ff3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_SellingGeneralAndAdministrativeExpenseDepreciationAmortizationAndProvisionExpense_019eee48-3a89-788a-a3ea-2aaf081e9bc7" xlink:href="nbx-20260630.xsd#nbx_SellingGeneralAndAdministrativeExpenseDepreciationAmortizationAndProvisionExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_019eee48-3a89-751c-8c1c-ebb962fb8d5c" xlink:to="loc_nbx_SellingGeneralAndAdministrativeExpenseDepreciationAmortizationAndProvisionExpense_019eee48-3a89-788a-a3ea-2aaf081e9bc7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/OperatingexpensesScheduleofPayrollCostsDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#OperatingexpensesScheduleofPayrollCostsDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/OperatingexpensesScheduleofPayrollCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EmployeeBenefitsExpense_019eee48-3a89-7032-92a4-b446206e3409" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EmployeeBenefitsExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans_019eee48-3a89-7690-9d0f-280a2fea64b6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_019eee48-3a89-7032-92a4-b446206e3409" xlink:to="loc_ifrs-full_PostemploymentBenefitExpenseDefinedBenefitPlans_019eee48-3a89-7690-9d0f-280a2fea64b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SocialSecurityContributions_019eee48-3a89-745a-8a58-a540e7d05f02" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SocialSecurityContributions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_019eee48-3a89-7032-92a4-b446206e3409" xlink:to="loc_ifrs-full_SocialSecurityContributions_019eee48-3a89-745a-8a58-a540e7d05f02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WagesAndSalaries_019eee48-3a89-7998-833c-c21089960b8a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WagesAndSalaries"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_019eee48-3a89-7032-92a4-b446206e3409" xlink:to="loc_ifrs-full_WagesAndSalaries_019eee48-3a89-7998-833c-c21089960b8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_019eee48-3a89-77f4-889e-36a0678e1fa6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EmployeeBenefitsExpense_019eee48-3a89-7032-92a4-b446206e3409" xlink:to="loc_ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees_019eee48-3a89-77f4-889e-36a0678e1fa6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/OperatingexpensesScheduleofDepreciationAmortizationandProvisionExpensesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#OperatingexpensesScheduleofDepreciationAmortizationandProvisionExpensesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/OperatingexpensesScheduleofDepreciationAmortizationandProvisionExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_nbx_DepreciationAmortizationAndProvisionExpenses_019eee48-3a89-7981-8d10-a01b8c37e706" xlink:href="nbx-20260630.xsd#nbx_DepreciationAmortizationAndProvisionExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19_019eee48-3a89-7ea6-97fe-c3267a073947" xlink:href="nbx-20260630.xsd#nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_DepreciationAmortizationAndProvisionExpenses_019eee48-3a89-7981-8d10-a01b8c37e706" xlink:to="loc_nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19_019eee48-3a89-7ea6-97fe-c3267a073947" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_ProvisionForRetirementBenefitObligationsNet_019eee48-3a89-776f-a03d-5bde898d4a2a" xlink:href="nbx-20260630.xsd#nbx_ProvisionForRetirementBenefitObligationsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_DepreciationAmortizationAndProvisionExpenses_019eee48-3a89-7981-8d10-a01b8c37e706" xlink:to="loc_nbx_ProvisionForRetirementBenefitObligationsNet_019eee48-3a89-776f-a03d-5bde898d4a2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19_019eee48-3a89-7e24-9597-441e691f9f25" xlink:href="nbx-20260630.xsd#nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AmortisationExpense_019eee48-3a89-779f-9189-b28daff25725" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AmortisationExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19_019eee48-3a89-7e24-9597-441e691f9f25" xlink:to="loc_ifrs-full_AmortisationExpense_019eee48-3a89-779f-9189-b28daff25725" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DepreciationExpense_019eee48-3a89-72d1-a4a4-7eaf26b0bd73" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DepreciationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19_019eee48-3a89-7e24-9597-441e691f9f25" xlink:to="loc_ifrs-full_DepreciationExpense_019eee48-3a89-72d1-a4a4-7eaf26b0bd73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_ReversalOfProvisionsForDisputesAndCharges_019eee48-3a89-7161-af8b-f1097850dffb" xlink:href="nbx-20260630.xsd#nbx_ReversalOfProvisionsForDisputesAndCharges"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19_019eee48-3a89-7e24-9597-441e691f9f25" xlink:to="loc_nbx_ReversalOfProvisionsForDisputesAndCharges_019eee48-3a89-7161-af8b-f1097850dffb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProvisionUsedOtherProvisions_01a0aa02-c9d7-7af2-987f-448a0ac5ece6" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProvisionUsedOtherProvisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19_019eee48-3a89-7e24-9597-441e691f9f25" xlink:to="loc_ifrs-full_ProvisionUsedOtherProvisions_01a0aa02-c9d7-7af2-987f-448a0ac5ece6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_ImpairmentOfCurrentAssets_01a086c3-db05-73c0-9232-d13e22ac6429" xlink:href="nbx-20260630.xsd#nbx_ImpairmentOfCurrentAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_DepreciationAmortizationAndProvisionExpensesExcludingIAS19_019eee48-3a89-7e24-9597-441e691f9f25" xlink:to="loc_nbx_ImpairmentOfCurrentAssets_01a086c3-db05-73c0-9232-d13e22ac6429" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/OperatingexpensesScheduleofOtherOperatingIncomeExpensesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#OperatingexpensesScheduleofOtherOperatingIncomeExpensesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/OperatingexpensesScheduleofOtherOperatingIncomeExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_019eee48-3a89-7f86-9b52-c62d91897179" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_OtherNonrecurringExpenses_019eee48-3a89-7192-a35e-4dbd93104733" xlink:href="nbx-20260630.xsd#nbx_OtherNonrecurringExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherOperatingIncomeExpense_019eee48-3a89-7f86-9b52-c62d91897179" xlink:to="loc_nbx_OtherNonrecurringExpenses_019eee48-3a89-7192-a35e-4dbd93104733" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_OtherNonrecurringsIncome_019eee48-3a89-7d1a-a8b7-861156c6acb6" xlink:href="nbx-20260630.xsd#nbx_OtherNonrecurringsIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherOperatingIncomeExpense_019eee48-3a89-7f86-9b52-c62d91897179" xlink:to="loc_nbx_OtherNonrecurringsIncome_019eee48-3a89-7d1a-a8b7-861156c6acb6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/NetfinancialincomelossScheduleofNetFinancialIncomeLossDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#NetfinancialincomelossScheduleofNetFinancialIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/NetfinancialincomelossScheduleofNetFinancialIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_019eee48-3b26-7832-8872-4bfde39e7218" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestIncomeOnCashAndCashEquivalents_019eee48-3b26-73df-9122-012a0edc113b" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestIncomeOnCashAndCashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_019eee48-3b26-7832-8872-4bfde39e7218" xlink:to="loc_ifrs-full_InterestIncomeOnCashAndCashEquivalents_019eee48-3b26-73df-9122-012a0edc113b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetForeignExchangeGain_019eee48-3b26-7c8b-a770-08f18c561c94" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NetForeignExchangeGain"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncome_019eee48-3b26-7832-8872-4bfde39e7218" xlink:to="loc_ifrs-full_NetForeignExchangeGain_019eee48-3b26-7c8b-a770-08f18c561c94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_019f3bb8-5955-7352-80b2-a515edacb58e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestRevenueExpense_019f3bb8-5955-7e6f-be48-b99056e1d5eb" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestRevenueExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_019f3bb8-5955-7352-80b2-a515edacb58e" xlink:to="loc_ifrs-full_InterestRevenueExpense_019f3bb8-5955-7e6f-be48-b99056e1d5eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_DebtRestructuringValuationImpact_019f3bb8-5955-7b6e-acf7-ede26e4b4c2d" xlink:href="nbx-20260630.xsd#nbx_DebtRestructuringValuationImpact"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_019f3bb8-5955-7352-80b2-a515edacb58e" xlink:to="loc_nbx_DebtRestructuringValuationImpact_019f3bb8-5955-7b6e-acf7-ede26e4b4c2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_019f3bb8-5955-7c55-b2ba-c210391b7790" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_019f3bb8-5955-7352-80b2-a515edacb58e" xlink:to="loc_ifrs-full_InterestExpenseOnLeaseLiabilities_019f3bb8-5955-7c55-b2ba-c210391b7790" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss_019f3bb8-5955-7fda-b03b-d0d15e166f6e" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceCosts_019f3bb8-5955-7352-80b2-a515edacb58e" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss_019f3bb8-5955-7fda-b03b-d0d15e166f6e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/RelatedpartiesScheduleofKeyManagementPersonnelCompensationDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#RelatedpartiesScheduleofKeyManagementPersonnelCompensationDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/RelatedpartiesScheduleofKeyManagementPersonnelCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensation_019eee48-3b26-75de-acc3-b01ced8c5ab4" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensation"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_019eee48-3b26-7a91-9637-082ae6038f53" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019eee48-3b26-75de-acc3-b01ced8c5ab4" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationShorttermEmployeeBenefits_019eee48-3b26-7a91-9637-082ae6038f53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment_019eee48-3b26-7fa2-bd65-a559b1a1d506" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019eee48-3b26-75de-acc3-b01ced8c5ab4" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment_019eee48-3b26-7fa2-bd65-a559b1a1d506" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationPostemploymentBenefits_01a06b22-0ee0-7a82-9c1a-6bf9fb603d0a" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationPostemploymentBenefits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019eee48-3b26-75de-acc3-b01ced8c5ab4" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationPostemploymentBenefits_01a06b22-0ee0-7a82-9c1a-6bf9fb603d0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_KeyManagementPersonnelCompensationOtherLongtermBenefits_01a06b25-ea76-7f0b-b93e-c0a347bd6d21" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationOtherLongtermBenefits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_KeyManagementPersonnelCompensation_019eee48-3b26-75de-acc3-b01ced8c5ab4" xlink:to="loc_ifrs-full_KeyManagementPersonnelCompensationOtherLongtermBenefits_01a06b25-ea76-7f0b-b93e-c0a347bd6d21" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://nanobiotix.com/role/RelatedpartiesScheduleofDisclosureofTransactionsBetweenLiabilitiesandReceivablesDetails" xlink:type="simple" xlink:href="nbx-20260630.xsd#RelatedpartiesScheduleofDisclosureofTransactionsBetweenLiabilitiesandReceivablesDetails"/>
  <link:calculationLink xlink:role="http://nanobiotix.com/role/RelatedpartiesScheduleofDisclosureofTransactionsBetweenLiabilitiesandReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_nbx_NetAmountsReceivablePayableRelatedPartyTransactions_019eee48-3b26-7284-89ea-ec5e8ae680fb" xlink:href="nbx-20260630.xsd#nbx_NetAmountsReceivablePayableRelatedPartyTransactions"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AmountsReceivableRelatedPartyTransactions_019eee48-3b26-7272-8f0d-4da0db436990" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AmountsReceivableRelatedPartyTransactions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_NetAmountsReceivablePayableRelatedPartyTransactions_019eee48-3b26-7284-89ea-ec5e8ae680fb" xlink:to="loc_ifrs-full_AmountsReceivableRelatedPartyTransactions_019eee48-3b26-7272-8f0d-4da0db436990" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AmountsPayableRelatedPartyTransactions_019eee48-3b26-73ac-9425-5d21ef87a0d7" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AmountsPayableRelatedPartyTransactions"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_NetAmountsReceivablePayableRelatedPartyTransactions_019eee48-3b26-7284-89ea-ec5e8ae680fb" xlink:to="loc_ifrs-full_AmountsPayableRelatedPartyTransactions_019eee48-3b26-73ac-9425-5d21ef87a0d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nbx_NetCollectionsPaymentsFromRelatedParty_019eee48-3b26-7d69-82ca-d092420d1335" xlink:href="nbx-20260630.xsd#nbx_NetCollectionsPaymentsFromRelatedParty"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToRelatedParties_019eee48-3b26-72f8-a70c-024c0d61a38d" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToRelatedParties"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_NetCollectionsPaymentsFromRelatedParty_019eee48-3b26-7d69-82ca-d092420d1335" xlink:to="loc_ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToRelatedParties_019eee48-3b26-72f8-a70c-024c0d61a38d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAdvancesAndLoansMadeToRelatedParties_019eee48-3b26-7e72-a60a-075cd6ade783" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAdvancesAndLoansMadeToRelatedParties"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_nbx_NetCollectionsPaymentsFromRelatedParty_019eee48-3b26-7d69-82ca-d092420d1335" xlink:to="loc_ifrs-full_CashAdvancesAndLoansMadeToRelatedParties_019eee48-3b26-7e72-a60a-075cd6ade783" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
